1,2-dilinoleoyl-gpc (18:2/18:2) to linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2]*

Numerator Metabolite

Structure of 1,2-dilinoleoyl-gpc (18:2/18:2)
Metabolite Accession: GCST90200030
Name: 1,2-dilinoleoyl-gpc (18:2/18:2)
Hmdb Id: HMDB0008138
Super Pathway: NA
Sub Pathway: NA
Inchikey: FVXDQWZBHIXIEJ

Denominator Metabolite

Structure of linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2]*
Metabolite Accession: GCST90200109
Name: linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2]*
Hmdb Id: HMDB0007257
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRECEGQUDDMNAQ

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.618
Position:
61588305
SE (Ratio):
0.024
Effect Allele:
G
Z-score (Ratio):
25.881
Reference Allele:
A
-log10(P):
-338.403
MAF:
0.344
Beta (Num):
0.291
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.327
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Phospholipid biosynthesis.3[1]

Denominator Metabolite Explanation:

Glycerolipid metabolism, Arachidonic acid metabolism.4[1], 5[2], 6[3]

Ratio Explanation:

This ratio reflects the efficiency of FADS-catalyzed conversion of linoleic acid (18:2) to arachidonic acid (20:4), a rate-limiting step in fatty acid metabolism.2[1], 4[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters desaturase activity, changing the balance of 18:2 and 20:4 fatty acids.2[1], 7[2] This dysregulation of fatty acid metabolism is causally linked to disorders of lipoprotein metabolism and pure hypercholesterolemia, likely through effects on lipid particle composition and concentration.8[3], 7[4]

Phenotype Driver:

Metabolite-centric[both]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data