1,2-dilinoleoyl-gpc (18:2/18:2) to arachidonoylcarnitine (c20:4)

Numerator Metabolite

Structure of 1,2-dilinoleoyl-gpc (18:2/18:2)
Metabolite Accession: GCST90200030
Name: 1,2-dilinoleoyl-gpc (18:2/18:2)
Hmdb Id: HMDB0008138
Super Pathway: NA
Sub Pathway: NA
Inchikey: FVXDQWZBHIXIEJ

Denominator Metabolite

Structure of arachidonoylcarnitine (c20:4)
Metabolite Accession: GCST90200150
Name: arachidonoylcarnitine (c20:4)
Hmdb Id: HMDB0006455
Super Pathway: NA
Sub Pathway: NA
Inchikey: RBFQHRALHSUPIA

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.562
Position:
61569830
SE (Ratio):
0.024
Effect Allele:
T
Z-score (Ratio):
23.872
Reference Allele:
C
-log10(P):
-288.325
MAF:
0.340
Beta (Num):
0.295
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.266
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Linoleic acid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid metabolism, Carnitine shuttle.6[1], 7[2], 8[3]

Ratio Explanation:

This ratio reflects FADS desaturase activity, comparing the linoleic acid (18:2) precursor in a phospholipid to its downstream product, arachidonic acid (20:4), as a carnitine conjugate.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity alters the PUFA profile, increasing the precursor-to-product ratio. This dysregulation of fatty acid metabolism is linked to hypercholesterolemia and inflammatory conditions like asthma and IBD through effects on lipid mediators and plasma lipoprotein levels.9[1], 10[2], 11[3], 12[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data