2-hydroxybutyrate/2-hydroxyisobutyrate to 3-hydroxylaurate

Numerator Metabolite

Structure of 2-hydroxybutyrate/2-hydroxyisobutyrate
Metabolite Accession: GCST90200032
Name: 2-hydroxybutyrate/2-hydroxyisobutyrate
Hmdb Id: HMDB0000729,HMDB00008
Super Pathway: NA
Sub Pathway: NA
Inchikey: BWLBGMIXKSTLSX

Denominator Metabolite

Structure of 3-hydroxylaurate
Metabolite Accession: GCST90199700
Name: 3-hydroxylaurate
Hmdb Id: HMDB0000387
Super Pathway: NA
Sub Pathway: NA
Inchikey: MUCMKTPAZLSKTL

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.150
Position:
151879761
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
9.392
Reference Allele:
G
-log10(P):
-46.580
MAF:
0.318
Beta (Num):
0.045
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.105
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Amino acid catabolism (threonine, methionine), glutathione synthesis.7[1], 8[2], 9[3]

Denominator Metabolite Explanation:

Fatty acid metabolism (beta-oxidation and biosynthesis).10[1], 11[2]

Ratio Explanation:

The ratio may reflect THEM4's activity in mitochondrial fatty acid metabolism (denominator) relative to amino acid catabolism and oxidative stress (numerator).7[1], 8[2], 4[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data