sphingomyelin (d18:2/23:0, d18:1/23:1, d17:1/24:1)* to 1-oleoyl-gpi (18:1)

Numerator Metabolite

Metabolite Accession: GCST90200033
Name: sphingomyelin (d18:2/23:0, d18:1/23:1, d17:1/24:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-oleoyl-gpi (18:1)
Metabolite Accession: GCST90199822
Name: 1-oleoyl-gpi (18:1)
Hmdb Id: HMDB0061693
Super Pathway: NA
Sub Pathway: NA
Inchikey: UGDOFRYHDCDVHD

Associated Genomic Regions

Region: rs174599

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
-0.174
Position:
61621556
SE (Ratio):
0.020
Effect Allele:
C
Z-score (Ratio):
-8.733
Reference Allele:
G
-log10(P):
-40.534
MAF:
0.374
Beta (Num):
-0.076
Novel Locus:
Yes ✔️
SE (Num):
0.014
Beta (Den):
0.098
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS3 FADS1 RAB3IL1 FEN1

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid synthesis5[1], 6[2]

Denominator Metabolite Explanation:

Glycosylphosphatidylinositol (GPI) anchor biosynthesis7[1], 8[2]

Ratio Explanation:

The ratio reflects the balance between sphingolipid and GPI-anchor synthesis; FADS enzymes influence the fatty acid composition of lipids in both pathways.9[1], 10[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered FADS1/FADS2 activity impacts the composition of sphingolipids and GPI-anchored proteins, affecting lipoprotein metabolism and inflammatory responses, which are linked to thrombophlebitis and dyslipidaemias.11[1], 12[2], 13[3], 14[4], 15[5], 16[6]

Phenotype Driver:

Gene-centric:FADS1, FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data