sphingomyelin (d18:2/23:0, d18:1/23:1, d17:1/24:1)* to 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*

Numerator Metabolite

Metabolite Accession: GCST90200033
Name: sphingomyelin (d18:2/23:0, d18:1/23:1, d17:1/24:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Metabolite Accession: GCST90200075
Name: 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Hmdb Id: HMDB0011343
Super Pathway: NA
Sub Pathway: NA
Inchikey: LJVXDBWIBQQKFU

Associated Genomic Regions

Region: rs174580

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.244
Position:
61606642
SE (Ratio):
0.020
Effect Allele:
G
Z-score (Ratio):
-12.386
Reference Allele:
A
-log10(P):
-79.458
MAF:
0.350
Beta (Num):
-0.073
Novel Locus:
No
SE (Num):
0.014
Beta (Den):
0.171
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FADS3 FEN1 TMEM258

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid metabolism.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Plasmalogen biosynthesis.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects FADS-mediated desaturation activity, influencing the fatty acid composition of both sphingolipids and plasmalogens, which are key components of cellular membranes.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS gene variants alter polyunsaturated fatty acid metabolism, impacting cell membrane composition and inflammatory pathways.10[1], 11[2] This influences susceptibility to inflammatory conditions like asthma and dermatitis and cardiometabolic phenotypes such as hypercholesterolemia and valvular heart disease.10[3], 12[4], 13[5], 14[6], 15[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data