tricosanoyl sphingomyelin (d18:1/23:0)* to palmitoyl dihydrosphingomyelin (d18:0/16:0)*

Numerator Metabolite

Structure of tricosanoyl sphingomyelin (d18:1/23:0)*
Metabolite Accession: GCST90200034
Name: tricosanoyl sphingomyelin (d18:1/23:0)*
Hmdb Id: HMDB0012105
Super Pathway: NA
Sub Pathway: NA
Inchikey: SXZWBNWTCVLZJN

Denominator Metabolite

Structure of palmitoyl dihydrosphingomyelin (d18:0/16:0)*
Metabolite Accession: GCST90200035
Name: palmitoyl dihydrosphingomyelin (d18:0/16:0)*
Hmdb Id: HMDB0010168
Super Pathway: NA
Sub Pathway: NA
Inchikey: QHZIGNLCLJPLCU

Associated Genomic Regions

Region: rs7160525

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
0.211
Position:
64232220
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
11.568
Reference Allele:
G
-log10(P):
-69.585
MAF:
0.164
Beta (Num):
0.026
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.185
SE (Den):
0.020
No CNV overlap
rQTL cluster:
47
Reaction Distance:
NA
Closest Genes:
SGPP1 SYNE2 WDR89 PPP2R5E ESR2

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid metabolism.3[1]

Denominator Metabolite Explanation:

Sphingolipid metabolism.3[1], 4[2]

Ratio Explanation:

The ratio compares a very-long-chain sphingomyelin to a long-chain dihydrosphingomyelin, potentially reflecting altered ceramide synthase, fatty acid elongation, or desaturase activity downstream of SGPP1.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered SGPP1 function likely modifies sphingolipid composition, affecting lipoprotein metabolism and triglyceride levels.3[1], 5[2], 6[3] Changes in sphingolipid balance, particularly ceramide and S1P levels, are also linked to insulin resistance and glucose homeostasis, impacting HbA1c.7[4], 8[5]

Phenotype Driver:

Gene-centric:SGPP1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data