palmitoyl dihydrosphingomyelin (d18:0/16:0)* to behenoyl sphingomyelin (d18:1/22:0)*

Numerator Metabolite

Structure of palmitoyl dihydrosphingomyelin (d18:0/16:0)*
Metabolite Accession: GCST90200035
Name: palmitoyl dihydrosphingomyelin (d18:0/16:0)*
Hmdb Id: HMDB0010168
Super Pathway: NA
Sub Pathway: NA
Inchikey: QHZIGNLCLJPLCU

Denominator Metabolite

Structure of behenoyl sphingomyelin (d18:1/22:0)*
Metabolite Accession: GCST90199997
Name: behenoyl sphingomyelin (d18:1/22:0)*
Hmdb Id: HMDB0012103
Super Pathway: NA
Sub Pathway: NA
Inchikey: FJJANLYCZUNFSE

Associated Genomic Regions

Region: rs7160525

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.250
Position:
64232220
SE (Ratio):
0.021
Effect Allele:
A
Z-score (Ratio):
-11.725
Reference Allele:
G
-log10(P):
-71.431
MAF:
0.164
Beta (Num):
-0.185
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.065
SE (Den):
0.020
No CNV overlap
rQTL cluster:
47
Reaction Distance:
NA
Closest Genes:
SGPP1 SYNE2 WDR89 PPP2R5E ESR2

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid de novo synthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Sphingolipid metabolism.3[1], 5[2]

Ratio Explanation:

Ratio may reflect the balance between de novo sphingolipid synthesis (dihydrosphingomyelin) and downstream ceramide modification/salvage pathways (sphingomyelin).3[1], 6[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered SGPP1 function likely modifies sphingolipid pools, including ceramides and sphingomyelins, which are integral to lipoprotein structure and are implicated in insulin resistance. This dysregulation contributes to lipoprotein metabolism disorders, affecting triglycerides and HbA1c levels.7[1], 8[2], 9[3]

Phenotype Driver:

Gene-centric:SGPP1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data