1-stearoyl-2-linoleoyl-gpc (18:0/18:2)* to adrenate (22:4n6)

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Metabolite Accession: GCST90200037
Name: 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Hmdb Id: HMDB0008039
Super Pathway: NA
Sub Pathway: NA
Inchikey: FORFDCPQKJHEBF

Denominator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.410
Position:
61569830
SE (Ratio):
0.024
Effect Allele:
T
Z-score (Ratio):
16.921
Reference Allele:
C
-log10(P):
-146.218
MAF:
0.340
Beta (Num):
0.227
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.183
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Phospholipid biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.6[1]

Ratio Explanation:

The ratio reflects the enzymatic efficiency of FADS1/FADS2 in converting shorter-chain fatty acids, represented by the numerator, into long-chain polyunsaturated fatty acids like the denominator.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity, indicated by a higher ratio, is associated with altered lipid profiles, including pure hypercholesterolaemia, and skin conditions like follicular cysts.7[1], 8[2], 9[3] This suggests a link between fatty acid metabolism and cholesterol homeostasis, as well as skin health.

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data