1-stearoyl-2-linoleoyl-gpc (18:0/18:2)* to 1-stearoyl-gpc (18:0)

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Metabolite Accession: GCST90200037
Name: 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Hmdb Id: HMDB0008039
Super Pathway: NA
Sub Pathway: NA
Inchikey: FORFDCPQKJHEBF

Denominator Metabolite

Structure of 1-stearoyl-gpc (18:0)
Metabolite Accession: GCST90199732
Name: 1-stearoyl-gpc (18:0)
Hmdb Id: HMDB0010384
Super Pathway: NA
Sub Pathway: NA
Inchikey: IHNKQIMGVNPMTC

Associated Genomic Regions

Region: rs174554

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.323
Position:
61579463
SE (Ratio):
0.016
Effect Allele:
G
Z-score (Ratio):
20.456
Reference Allele:
A
-log10(P):
-212.477
MAF:
0.338
Beta (Num):
0.227
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.096
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylcholine biosynthesis.5[1], 6[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Lysophospholipid catabolism.7[1], 8[2]

Ratio Explanation:

The ratio of PC(18:0/18:2) to its precursor LysoPC(18:0) reflects phospholipid remodeling, specifically reacylation via the Lands cycle, influenced by FADS-mediated PUFA availability.9[1], 10[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters polyunsaturated fatty acid levels, modifying this ratio.11[1] This dysregulation of lipid metabolism is strongly associated with hypercholesterolemia and can influence inflammatory skin conditions like follicular cysts, both of which show significant Mendelian randomization evidence.12[2]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data