1-stearoyl-2-linoleoyl-gpc (18:0/18:2)* to 1-stearoyl-gpe (18:0)

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Metabolite Accession: GCST90200037
Name: 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Hmdb Id: HMDB0008039
Super Pathway: NA
Sub Pathway: NA
Inchikey: FORFDCPQKJHEBF

Denominator Metabolite

Structure of 1-stearoyl-gpe (18:0)
Metabolite Accession: GCST90199772
Name: 1-stearoyl-gpe (18:0)
Hmdb Id: HMDB0011130
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBYWOYAFBUOUFP

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.298
Position:
61557803
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
16.329
Reference Allele:
T
-log10(P):
-136.334
MAF:
0.347
Beta (Num):
0.220
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.078
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism.4[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.5[1]

Ratio Explanation:

The ratio reflects the balance between a phosphatidylcholine and a lysophosphatidylethanolamine, likely modulated by FADS1 activity which influences the fatty acid composition of phospholipids.6[1], 7[2], 8[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1 variants impact polyunsaturated fatty acid synthesis, altering phospholipid profiles.9[1], 10[2] This metabolic shift is reflected in the ratio and is associated with an increased risk for pure hypercholesterolemia, a phenotype linked to FADS1 function in lipid and cholesterol metabolism.2[3], 11[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data