1-stearoyl-2-linoleoyl-gpc (18:0/18:2)* to sphingomyelin (d18:1/18:1, d18:2/18:0)

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Metabolite Accession: GCST90200037
Name: 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Hmdb Id: HMDB0008039
Super Pathway: NA
Sub Pathway: NA
Inchikey: FORFDCPQKJHEBF

Denominator Metabolite

Structure of sphingomyelin (d18:1/18:1, d18:2/18:0)
Metabolite Accession: GCST90199878
Name: sphingomyelin (d18:1/18:1, d18:2/18:0)
Hmdb Id: HMDB0012101
Super Pathway: NA
Sub Pathway: NA
Inchikey: NBEADXWAAWCCDG

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.335
Position:
61588305
SE (Ratio):
0.021
Effect Allele:
G
Z-score (Ratio):
15.852
Reference Allele:
A
-log10(P):
-128.642
MAF:
0.344
Beta (Num):
0.223
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.112
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Sphingolipid metabolism.7[1], 8[2], 9[3], 10[4]

Ratio Explanation:

The ratio indicates the balance between major membrane lipid pools, glycerophospholipids and sphingolipids, which is influenced by FADS-mediated fatty acid desaturation.11[1], 12[2], 13[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in the FADS1/FADS2 cluster alters polyunsaturated fatty acid metabolism, which impacts the balance of membrane lipids. This dysregulates systemic lipid profiles and inflammatory responses, contributing to phenotypes like hypercholesterolemia, inflammatory bowel disease, and asthma.1[1], 3[2], 14[3], 15[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data