1-stearoyl-2-linoleoyl-gpc (18:0/18:2)* to 1-(1-enyl-palmitoyl)-gpc (p-16:0)*

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Metabolite Accession: GCST90200037
Name: 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Hmdb Id: HMDB0008039
Super Pathway: NA
Sub Pathway: NA
Inchikey: FORFDCPQKJHEBF

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-gpc (p-16:0)*
Metabolite Accession: GCST90199899
Name: 1-(1-enyl-palmitoyl)-gpc (p-16:0)*
Hmdb Id: HMDB0010407
Super Pathway: NA
Sub Pathway: NA
Inchikey: HTZINLFNXLXRBC

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.389
Position:
61588305
SE (Ratio):
0.020
Effect Allele:
G
Z-score (Ratio):
19.645
Reference Allele:
A
-log10(P):
-196.165
MAF:
0.344
Beta (Num):
0.223
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.165
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Linoleate metabolism.4[1]

Denominator Metabolite Explanation:

Ether lipid metabolism, Plasmalogen biosynthesis.5[1], 6[2]

Ratio Explanation:

This ratio reflects FADS enzyme activity, contrasting a linoleic acid-containing phosphatidylcholine with a plasmalogen, potentially indicating shifts in glycerophospholipid and fatty acid metabolism.7[1], 8[2], 9[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters desaturase activity, impacting polyunsaturated fatty acid pools, which is reflected in the ratio. This dysregulation is linked to pure hypercholesterolemia and cholelithiasis through the genes' established roles in systemic lipid metabolism and inflammatory processes.10[1], 8[2], 11[3], 12[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data