1-stearoyl-2-linoleoyl-gpc (18:0/18:2)* to sphingomyelin (d18:2/14:0, d18:1/14:1)*

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Metabolite Accession: GCST90200037
Name: 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Hmdb Id: HMDB0008039
Super Pathway: NA
Sub Pathway: NA
Inchikey: FORFDCPQKJHEBF

Denominator Metabolite

Metabolite Accession: GCST90199975
Name: sphingomyelin (d18:2/14:0, d18:1/14:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174554

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.314
Position:
61579463
SE (Ratio):
0.017
Effect Allele:
G
Z-score (Ratio):
18.070
Reference Allele:
A
-log10(P):
-166.383
MAF:
0.338
Beta (Num):
0.227
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.087
SE (Den):
0.013
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Phospholipid biosynthesis1[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Sphingolipid metabolism8[1], 9[2], 7[3], 10[4], 11[5]

Ratio Explanation:

The ratio reflects the balance between glycerophospholipid and sphingolipid synthesis, which is influenced by FADS enzymes that regulate fatty acid unsaturation for incorporation into these lipids.1[1], 2[2], 9[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The FADS gene cluster influences the saturation of fatty acids incorporated into both glycerophospholipids and sphingolipids, affecting cell membrane composition and signaling.12[1], 9[2] Altered FADS activity, as suggested by the eQTL data, may lead to dyslipidemia, including pure hypercholesterolemia, by modifying the balance of these lipid species.13[3], 14[4], 15[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data