1-stearoyl-2-linoleoyl-gpc (18:0/18:2)* to sphingomyelin (d18:2/24:1, d18:1/24:2)*

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Metabolite Accession: GCST90200037
Name: 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Hmdb Id: HMDB0008039
Super Pathway: NA
Sub Pathway: NA
Inchikey: FORFDCPQKJHEBF

Denominator Metabolite

Metabolite Accession: GCST90200040
Name: sphingomyelin (d18:2/24:1, d18:1/24:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.301
Position:
61588305
SE (Ratio):
0.019
Effect Allele:
G
Z-score (Ratio):
15.945
Reference Allele:
A
-log10(P):
-130.121
MAF:
0.344
Beta (Num):
0.223
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.077
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Sphingolipid metabolism.4[1]

Ratio Explanation:

The ratio of phosphatidylcholine (PC) to sphingomyelin (SM) reflects a balance in membrane composition; FADS1 influences the linoleoyl component of the PC numerator.1[1], 5[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic FADS1 variation alters fatty acid desaturation, affecting the PC-to-SM ratio.1[1], 6[2] This lipid imbalance is linked to hypercholesterolemia and other cardiometabolic phenotypes.7[3], 8[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data