1-stearoyl-2-linoleoyl-gpc (18:0/18:2)* to 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Metabolite Accession: GCST90200037
Name: 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Hmdb Id: HMDB0008039
Super Pathway: NA
Sub Pathway: NA
Inchikey: FORFDCPQKJHEBF

Denominator Metabolite

Structure of 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Metabolite Accession: GCST90200041
Name: 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Hmdb Id: HMDB0007970
Super Pathway: NA
Sub Pathway: NA
Inchikey: PZNPLUBHRSSFHT

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.435
Position:
61557803
SE (Ratio):
0.017
Effect Allele:
C
Z-score (Ratio):
26.214
Reference Allele:
T
-log10(P):
-347.080
MAF:
0.347
Beta (Num):
0.220
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.215
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

Region: rs12928099

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
16
Beta (Ratio):
-0.158
Position:
15150505
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
-9.023
Reference Allele:
C
-log10(P):
-43.146
MAF:
0.291
Beta (Num):
-0.091
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.068
SE (Den):
0.017
No CNV overlap
rQTL cluster:
34
Reaction Distance:
NA
Closest Genes:
PDXDC1 NTAN1 RRN3 NPIPA1 NOMO1

LLM Analysis

Numerator Metabolite Explanation:

Phospholipid Biosynthesis, Fatty acid metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Phospholipid Biosynthesis, Fatty acid metabolism.5[1], 4[2]

Ratio Explanation:

The ratio reflects the activity of desaturase enzymes, likely FADS1/FADS2, in converting saturated and monounsaturated fatty acids to polyunsaturated fatty acids within phospholipids.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity, indicated by a lower ratio, alters lipid composition, influencing inflammatory pathways and lipoprotein metabolism, which are linked to hypercholesterolemia and cardiovascular phenotypes.6[1], 7[2], 8[3]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data