1-stearoyl-2-linoleoyl-gpc (18:0/18:2)* to 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Metabolite Accession: GCST90200037
Name: 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Hmdb Id: HMDB0008039
Super Pathway: NA
Sub Pathway: NA
Inchikey: FORFDCPQKJHEBF

Denominator Metabolite

Metabolite Accession: GCST90200051
Name: 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs12928099

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
-0.252
Position:
15150505
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
-13.715
Reference Allele:
C
-log10(P):
-96.903
MAF:
0.291
Beta (Num):
-0.091
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.162
SE (Den):
0.017
No CNV overlap
rQTL cluster:
34
Reaction Distance:
NA
Closest Genes:
PDXDC1 NTAN1 RRN3 NPIPA1 NOMO1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylcholine biosynthesis.3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylcholine biosynthesis.3[1], 6[2]

Ratio Explanation:

The ratio reflects the balance between two specific phosphatidylcholine species, likely indicating altered phospholipid remodeling activity influenced by genetic factors.7[1]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in NOMO1, a protein essential for the endoplasmic reticulum's structure where lipid synthesis occurs, may alter phospholipid profiles.1[1] This is associated with changes in plasma HDL-cholesterol and triglyceride levels, which are key indicators of cardiovascular health.8[2], 9[3]

Phenotype Driver:

Gene-centric:NOMO1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data