1-stearoyl-2-linoleoyl-gpc (18:0/18:2)* to 1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)*

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Metabolite Accession: GCST90200037
Name: 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Hmdb Id: HMDB0008039
Super Pathway: NA
Sub Pathway: NA
Inchikey: FORFDCPQKJHEBF

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)*
Metabolite Accession: GCST90200057
Name: 1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)*
Hmdb Id: HMDB0007996
Super Pathway: NA
Sub Pathway: NA
Inchikey: MPQGNHKVOVYEEN

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.340
Position:
61557803
SE (Ratio):
0.020
Effect Allele:
C
Z-score (Ratio):
17.264
Reference Allele:
T
-log10(P):
-152.092
MAF:
0.347
Beta (Num):
0.220
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.120
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Phosphatidylcholine Biosynthesis, Phospholipid Metabolism.2[1], 3[2]

Denominator Metabolite Explanation:

Plasmalogen Biosynthesis, Phospholipid Metabolism.4[1], 3[2]

Ratio Explanation:

This ratio reflects the balance between a common phosphatidylcholine and a choline plasmalogen, influenced by FADS1's role in fatty acid desaturation.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 alters its desaturase activity, impacting the levels of specific fatty acids incorporated into phospholipids.5[1], 6[2] This altered lipid profile is associated with hypercholesterolemia and other metabolic disorders.7[3], 8[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data