1-stearoyl-2-linoleoyl-gpc (18:0/18:2)* to 1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)*

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Metabolite Accession: GCST90200037
Name: 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Hmdb Id: HMDB0008039
Super Pathway: NA
Sub Pathway: NA
Inchikey: FORFDCPQKJHEBF

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)*
Metabolite Accession: GCST90200060
Name: 1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)*
Hmdb Id: HMDB0011211
Super Pathway: NA
Sub Pathway: NA
Inchikey: QLEHHUPUHJPURI

Associated Genomic Regions

Region: rs964184

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.197
Position:
116648917
SE (Ratio):
0.024
Effect Allele:
G
Z-score (Ratio):
8.289
Reference Allele:
C
-log10(P):
-36.708
MAF:
0.131
Beta (Num):
0.081
Novel Locus:
Yes ✔️
SE (Num):
0.022
Beta (Den):
-0.117
SE (Den):
0.023
No CNV overlap
rQTL cluster:
248
Reaction Distance:
NA
Closest Genes:
ZNF259 BUD13 APOA5 APOA4 APOC3

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylcholine biosynthesis4[1], 5[2]

Denominator Metabolite Explanation:

Ether lipid metabolism, Plasmalogen synthesis6[1]

Ratio Explanation:

This ratio reflects the balance between a major diacyl-phosphatidylcholine and a choline plasmalogen, both key components of cell membranes and lipoproteins.7[1], 6[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in the APOA1/APOA5 gene cluster influence lipoprotein metabolism, which alters the composition of lipids like phosphatidylcholines and plasmalogens within lipoproteins, contributing to dyslipidemia and increased risk for cardiovascular diseases such as hypercholesterolemia and myocardial infarction.1[1], 8[2], 9[3]

Phenotype Driver:

Gene-centric:APOA5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data