1-stearoyl-2-linoleoyl-gpc (18:0/18:2)* to 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Metabolite Accession: GCST90200037
Name: 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Hmdb Id: HMDB0008039
Super Pathway: NA
Sub Pathway: NA
Inchikey: FORFDCPQKJHEBF

Denominator Metabolite

Structure of 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*
Metabolite Accession: GCST90200062
Name: 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*
Hmdb Id: HMDB0009789
Super Pathway: NA
Sub Pathway: NA
Inchikey: KIQYUSYSJTUGFZ

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.376
Position:
61569830
SE (Ratio):
0.021
Effect Allele:
T
Z-score (Ratio):
17.798
Reference Allele:
C
-log10(P):
-161.488
MAF:
0.340
Beta (Num):
0.227
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.149
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylcholine biosynthesis. 4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylinositol biosynthesis. 4[1], 7[2]

Ratio Explanation:

The ratio of a phosphatidylcholine with linoleic acid (18:2) to a phosphatidylinositol with arachidonic acid (20:4) reflects FADS1/FADS2 desaturase activity. 8[1], 2[2], 9[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters the conversion of linoleic acid to arachidonic acid, affecting the balance of pro-inflammatory and anti-inflammatory lipids. This dysregulation is linked to inflammatory conditions and metabolic disorders like hypercholesterolemia and cholelithiasis. 10[1], 11[2], 12[3], 13[4], 14[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data