1-stearoyl-2-linoleoyl-gpc (18:0/18:2)* to 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Metabolite Accession: GCST90200037
Name: 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Hmdb Id: HMDB0008039
Super Pathway: NA
Sub Pathway: NA
Inchikey: FORFDCPQKJHEBF

Denominator Metabolite

Structure of 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*
Metabolite Accession: GCST90200073
Name: 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*
Hmdb Id: HMDB0008147
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZZSZQATYGVHNLZ

Associated Genomic Regions

Region: rs102274

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.522
Position:
61557826
SE (Ratio):
0.017
Effect Allele:
C
Z-score (Ratio):
30.344
Reference Allele:
T
-log10(P):
-464.022
MAF:
0.341
Beta (Num):
0.224
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.298
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylcholine biosynthesis.7[1], 8[2], 9[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Arachidonic acid metabolism.

Ratio Explanation:

The ratio reflects the enzymatic activity of the FADS1/FADS2 gene cluster, where a lower ratio indicates more efficient conversion from linoleic to arachidonic acid.3[1], 4[2], 10[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 function, indicated by a higher ratio, alters fatty acid profiles. This is genetically associated with hypercholesterolemia and skin conditions like follicular cysts, potentially through inflammatory pathways influenced by arachidonic acid-derived eicosanoids.3[1], 4[2], 11[3]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data