1-stearoyl-2-linoleoyl-gpc (18:0/18:2)* to 1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)*

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Metabolite Accession: GCST90200037
Name: 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Hmdb Id: HMDB0008039
Super Pathway: NA
Sub Pathway: NA
Inchikey: FORFDCPQKJHEBF

Denominator Metabolite

Structure of 1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)*
Metabolite Accession: GCST90200078
Name: 1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)*
Hmdb Id: HMDB0007883
Super Pathway: NA
Sub Pathway: NA
Inchikey: SRQSAJRUMDQMMS

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.568
Position:
61569830
SE (Ratio):
0.021
Effect Allele:
T
Z-score (Ratio):
26.559
Reference Allele:
C
-log10(P):
-356.194
MAF:
0.340
Beta (Num):
0.227
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.341
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Phosphatidylcholine biosynthesis, Linoleic acid metabolism.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Phosphatidylcholine biosynthesis, Arachidonic acid metabolism.7[1], 4[2], 8[3], 9[4], 10[5], 11[6]

Ratio Explanation:

This ratio reflects FADS enzyme activity, where a higher value suggests lower conversion of linoleic acid (precursor) to arachidonic acid (product) containing phospholipids.12[1], 13[2], 4[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity alters the balance of omega-6 fatty acids, increasing precursors (like linoleoyl-GPC) and decreasing products (arachidonoyl-GPC).14[1] This shift impacts inflammatory potential and lipid profiles, linking to hypercholesterolemia, IBD, and asthma.2[2], 15[3], 16[4], 17[5], 18[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data