1-stearoyl-2-linoleoyl-gpc (18:0/18:2)* to arachidonoylcholine

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Metabolite Accession: GCST90200037
Name: 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Hmdb Id: HMDB0008039
Super Pathway: NA
Sub Pathway: NA
Inchikey: FORFDCPQKJHEBF

Denominator Metabolite

Structure of arachidonoylcholine
Metabolite Accession: GCST90200086
Name: arachidonoylcholine
Hmdb Id: HMDB0240583
Super Pathway: NA
Sub Pathway: NA
Inchikey: NJSSWIYQGNCVTH

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.418
Position:
61569830
SE (Ratio):
0.023
Effect Allele:
T
Z-score (Ratio):
18.256
Reference Allele:
C
-log10(P):
-169.767
MAF:
0.340
Beta (Num):
0.227
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.191
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism.4[1]

Denominator Metabolite Explanation:

Fatty acid/cholinergic signaling.5[1], 6[2]

Ratio Explanation:

This ratio reflects FADS1/FADS2 enzyme activity, representing the conversion of a linoleic acid-containing phosphatidylcholine to arachidonoylcholine, a downstream metabolite derived from arachidonic acid.1[1], 7[2], 8[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1/FADS2 variants alter enzyme activity, impacting the balance of pro- and anti-inflammatory lipids derived from omega-6 fatty acids.9[1], 10[2] This dysregulation is linked to various inflammatory and metabolic disorders like cholelithiasis, hypercholesterolemia, and type 2 diabetes.11[3], 9[4], 12[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data