1-stearoyl-2-linoleoyl-gpc (18:0/18:2)* to sphingomyelin (d17:2/16:0, d18:2/15:0)*

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Metabolite Accession: GCST90200037
Name: 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Hmdb Id: HMDB0008039
Super Pathway: NA
Sub Pathway: NA
Inchikey: FORFDCPQKJHEBF

Denominator Metabolite

Metabolite Accession: GCST90200125
Name: sphingomyelin (d17:2/16:0, d18:2/15:0)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174554

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.302
Position:
61579463
SE (Ratio):
0.017
Effect Allele:
G
Z-score (Ratio):
17.353
Reference Allele:
A
-log10(P):
-153.641
MAF:
0.338
Beta (Num):
0.227
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.075
SE (Den):
0.014
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Phospholipid biosynthesis.2[1], 3[2]

Denominator Metabolite Explanation:

Sphingolipid metabolism.4[1], 5[2], 6[3], 7[4]

Ratio Explanation:

This ratio compares phosphatidylcholine to sphingomyelin levels, potentially reflecting the balance between glycerophospholipid and sphingolipid pathways, influenced by FADS-mediated fatty acid metabolism.8[1], 9[2], 10[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in the FADS cluster alters fatty acid desaturation, affecting the PC/SM ratio.1[1] This dysregulation of lipid membrane composition can impact cholesterol homeostasis and lipoprotein metabolism, plausibly increasing the risk for pure hypercholesterolaemia, cholelithiasis, and type 2 diabetes.1[2], 11[3], 12[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data