1-stearoyl-2-linoleoyl-gpc (18:0/18:2)* to arachidoylcarnitine (c20)*

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Metabolite Accession: GCST90200037
Name: 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Hmdb Id: HMDB0008039
Super Pathway: NA
Sub Pathway: NA
Inchikey: FORFDCPQKJHEBF

Denominator Metabolite

Structure of arachidoylcarnitine (c20)*
Metabolite Accession: GCST90200135
Name: arachidoylcarnitine (c20)*
Hmdb Id: HMDB0006460
Super Pathway: NA
Sub Pathway: NA
Inchikey: SVJLJQBGUITFLI

Associated Genomic Regions

Region: rs174554

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.296
Position:
61579463
SE (Ratio):
0.018
Effect Allele:
G
Z-score (Ratio):
16.378
Reference Allele:
A
-log10(P):
-137.144
MAF:
0.338
Beta (Num):
0.227
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.069
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylcholine biosynthesis.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, Carnitine shuttle.7[1], 8[2], 9[3]

Ratio Explanation:

This ratio likely reflects FADS-mediated polyunsaturated fatty acid metabolism, contrasting a linoleoyl-containing phospholipid with the mitochondrial transport of a long-chain saturated fatty acid.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1/FADS2 variants alter polyunsaturated fatty acid synthesis, affecting the balance of inflammatory precursors and membrane lipids.10[1], 11[2], 12[3] This dysregulation contributes to phenotypes like cholelithiasis, type 2 diabetes, and inflammatory bowel disease, which have strong inflammatory and metabolic components.13[4], 14[5], 15[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data