1-stearoyl-2-linoleoyl-gpc (18:0/18:2)* to lignoceroylcarnitine (c24)*

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Metabolite Accession: GCST90200037
Name: 1-stearoyl-2-linoleoyl-gpc (18:0/18:2)*
Hmdb Id: HMDB0008039
Super Pathway: NA
Sub Pathway: NA
Inchikey: FORFDCPQKJHEBF

Denominator Metabolite

Structure of lignoceroylcarnitine (c24)*
Metabolite Accession: GCST90200137
Name: lignoceroylcarnitine (c24)*
Hmdb Id: HMDB0240665
Super Pathway: NA
Sub Pathway: NA
Inchikey: YDUFZFUYBBPVLJ

Associated Genomic Regions

Region: rs174554

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.285
Position:
61579463
SE (Ratio):
0.017
Effect Allele:
G
Z-score (Ratio):
16.465
Reference Allele:
A
-log10(P):
-138.576
MAF:
0.338
Beta (Num):
0.227
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.058
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid Metabolism5[1], 6[2], 7[3], 8[4]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation9[1], 10[2]

Ratio Explanation:

The ratio reflects the balance between glycerophospholipid synthesis, requiring fatty acid precursors, and fatty acid degradation, influenced by FADS desaturase activity.3[1], 11[2], 9[3], 6[4]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter polyunsaturated fatty acid metabolism, impacting the availability of substrates for both glycerophospholipid synthesis and beta-oxidation.3[1], 12[2], 11[3] This altered lipid metabolism is associated with dyslipidemia, cholelithiasis, and type 2 diabetes.13[4], 14[5], 15[6], 16[7], 17[8]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data