1-palmitoyl-2-palmitoleoyl-gpc (16:0/16:1)* to 1,2-dipalmitoyl-gpc (16:0/16:0)

Numerator Metabolite

Structure of 1-palmitoyl-2-palmitoleoyl-gpc (16:0/16:1)*
Metabolite Accession: GCST90200038
Name: 1-palmitoyl-2-palmitoleoyl-gpc (16:0/16:1)*
Hmdb Id: HMDB0007969
Super Pathway: NA
Sub Pathway: NA
Inchikey: QIBZFHLFHCIUOT

Denominator Metabolite

Structure of 1,2-dipalmitoyl-gpc (16:0/16:0)
Metabolite Accession: GCST90199660
Name: 1,2-dipalmitoyl-gpc (16:0/16:0)
Hmdb Id: HMDB0000564
Super Pathway: NA
Sub Pathway: NA
Inchikey: KILNVBDSWZSGLL

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.281
Position:
61557803
SE (Ratio):
0.019
Effect Allele:
C
Z-score (Ratio):
14.959
Reference Allele:
T
-log10(P):
-114.827
MAF:
0.346
Beta (Num):
0.060
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.221
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Phospholipid biosynthesis

Denominator Metabolite Explanation:

Phospholipid biosynthesis

Ratio Explanation:

This ratio reflects the activity of fatty acid desaturase enzymes which convert saturated fatty acids (16:0) to monounsaturated ones (16:1) within phosphatidylcholines.3[1], 4[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1 gene variants impact desaturase activity, altering the lipid profile, including the PC(16:0/16:1)-to-PC(16:0/16:0) ratio.3[1] This dysregulation of lipid metabolism is a known contributor to disorders like hypercholesterolaemia and the formation of cholesterol gallstones (Cholelithiasis).5[2], 6[3], 7[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data