1-palmitoyl-2-palmitoleoyl-gpc (16:0/16:1)* to palmitoylcarnitine (c16)

Numerator Metabolite

Structure of 1-palmitoyl-2-palmitoleoyl-gpc (16:0/16:1)*
Metabolite Accession: GCST90200038
Name: 1-palmitoyl-2-palmitoleoyl-gpc (16:0/16:1)*
Hmdb Id: HMDB0007969
Super Pathway: NA
Sub Pathway: NA
Inchikey: QIBZFHLFHCIUOT

Denominator Metabolite

Structure of palmitoylcarnitine (c16)
Metabolite Accession: GCST90199666
Name: palmitoylcarnitine (c16)
Hmdb Id: HMDB0000222
Super Pathway: NA
Sub Pathway: NA
Inchikey: XOMRRQXKHMYMOC

Associated Genomic Regions

Region: rs174544

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.149
Position:
61567753
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
8.217
Reference Allele:
C
-log10(P):
-36.109
MAF:
0.302
Beta (Num):
0.062
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
-0.086
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Phospholipid biosynthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, Carnitine shuttle.5[1], 6[2]

Ratio Explanation:

The ratio likely reflects the balance between fatty acid desaturation and incorporation into membrane phospholipids (numerator) versus transport into mitochondria for oxidation (denominator), influenced by FADS1.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 alters polyunsaturated fatty acid metabolism, which is reflected by the ratio.7[1], 8[2] This dysregulates inflammatory mediators and lipid profiles, plausibly contributing to the associated inflammatory (asthma, dermatitis) and metabolic (hypercholesterolemia, lipoprotein disorders) phenotypes.9[3], 10[4], 11[5], 12[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data