1-palmitoyl-2-palmitoleoyl-gpc (16:0/16:1)* to sphingomyelin (d18:2/14:0, d18:1/14:1)*

Numerator Metabolite

Structure of 1-palmitoyl-2-palmitoleoyl-gpc (16:0/16:1)*
Metabolite Accession: GCST90200038
Name: 1-palmitoyl-2-palmitoleoyl-gpc (16:0/16:1)*
Hmdb Id: HMDB0007969
Super Pathway: NA
Sub Pathway: NA
Inchikey: QIBZFHLFHCIUOT

Denominator Metabolite

Metabolite Accession: GCST90199975
Name: sphingomyelin (d18:2/14:0, d18:1/14:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174548

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.160
Position:
61571348
SE (Ratio):
0.017
Effect Allele:
G
Z-score (Ratio):
9.409
Reference Allele:
C
-log10(P):
-46.748
MAF:
0.309
Beta (Num):
0.063
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.097
SE (Den):
0.014
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Phosphatidylcholine Biosynthesis, Glycerophospholipid Metabolism

Denominator Metabolite Explanation:

Sphingolipid metabolism, Phosphosphingolipid pathway

Ratio Explanation:

The ratio reflects the activity of FADS1 in partitioning polyunsaturated fatty acids between glycerophospholipid (numerator) and sphingolipid (denominator) synthesis, impacting membrane composition.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1 activity alterations impact the synthesis of bioactive lipids, which influences lipid metabolism and inflammatory responses associated with hypercholesterolaemia, valvular heart disease, and asthma.4[1], 5[2], 6[3]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data