1-palmitoyl-2-palmitoleoyl-gpc (16:0/16:1)* to 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*

Numerator Metabolite

Structure of 1-palmitoyl-2-palmitoleoyl-gpc (16:0/16:1)*
Metabolite Accession: GCST90200038
Name: 1-palmitoyl-2-palmitoleoyl-gpc (16:0/16:1)*
Hmdb Id: HMDB0007969
Super Pathway: NA
Sub Pathway: NA
Inchikey: QIBZFHLFHCIUOT

Denominator Metabolite

Structure of 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*
Metabolite Accession: GCST90200054
Name: 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*
Hmdb Id: HMDB0005323
Super Pathway: NA
Sub Pathway: NA
Inchikey: DRIVXEVMDWCWLI

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.204
Position:
61592362
SE (Ratio):
0.017
Effect Allele:
G
Z-score (Ratio):
12.088
Reference Allele:
A
-log10(P):
-75.787
MAF:
0.345
Beta (Num):
0.064
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.140
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylcholine biosynthesis.5[1], 6[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylethanolamine biosynthesis.7[1], 8[2]

Ratio Explanation:

The ratio reflects fatty acid desaturase (FADS) activity, comparing a monounsaturated phosphatidylcholine to a phosphatidylethanolamine containing the FADS-product arachidonic acid (20:4).

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter the production of polyunsaturated fatty acids, reflected in the ratio.1[1], 9[2] This dysregulation of fatty acid metabolism is linked to an increased risk for dyslipidemia, pure hypercholesterolaemia, and other associated metabolic disorders.9[3], 10[4], 11[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data