1-palmitoyl-2-palmitoleoyl-gpc (16:0/16:1)* to 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*

Numerator Metabolite

Structure of 1-palmitoyl-2-palmitoleoyl-gpc (16:0/16:1)*
Metabolite Accession: GCST90200038
Name: 1-palmitoyl-2-palmitoleoyl-gpc (16:0/16:1)*
Hmdb Id: HMDB0007969
Super Pathway: NA
Sub Pathway: NA
Inchikey: QIBZFHLFHCIUOT

Denominator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Metabolite Accession: GCST90200080
Name: 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Hmdb Id: HMDB0009783
Super Pathway: NA
Sub Pathway: NA
Inchikey: PDLAMJKMOKWLAJ

Associated Genomic Regions

Region: rs4806498

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.165
Position:
54674742
SE (Ratio):
0.013
Effect Allele:
T
Z-score (Ratio):
-13.004
Reference Allele:
C
-log10(P):
-87.350
MAF:
0.425
Beta (Num):
0.012
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.178
SE (Den):
0.016
No CNV overlap
rQTL cluster:
6
Reaction Distance:
NA
Closest Genes:
TMC4 MBOAT7 LENG1 CNOT3 TSEN34

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Glycerophospholipid metabolism

Ratio Explanation:

The ratio of 1-palmitoyl-2-palmitoleoyl-gpc to 1-palmitoyl-2-oleoyl-gpi may reflect altered MBOAT7-mediated acyl chain remodeling, impacting membrane composition and downstream signaling.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced MBOAT7 function alters phosphatidylinositol acyl chains, potentially impacting platelet production and leading to changes in alkaline phosphatase levels, which are associated with liver inflammation.6[1], 7[2], 8[3], 9[4], 10[5], 11[6], 12[7]

Phenotype Driver:

Gene-centric:MBOAT7

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data