1-palmitoyl-2-palmitoleoyl-gpc (16:0/16:1)* to nisinate (24:6n3)

Numerator Metabolite

Structure of 1-palmitoyl-2-palmitoleoyl-gpc (16:0/16:1)*
Metabolite Accession: GCST90200038
Name: 1-palmitoyl-2-palmitoleoyl-gpc (16:0/16:1)*
Hmdb Id: HMDB0007969
Super Pathway: NA
Sub Pathway: NA
Inchikey: QIBZFHLFHCIUOT

Denominator Metabolite

Structure of nisinate (24:6n3)
Metabolite Accession: GCST90200122
Name: nisinate (24:6n3)
Hmdb Id: HMDB0013025
Super Pathway: NA
Sub Pathway: NA
Inchikey: YHGJECVSSKXFCJ

Associated Genomic Regions

Region: rs174568

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.218
Position:
61593816
SE (Ratio):
0.023
Effect Allele:
T
Z-score (Ratio):
9.450
Reference Allele:
C
-log10(P):
-47.138
MAF:
0.339
Beta (Num):
0.062
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.156
SE (Den):
0.022
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylcholine biosynthesis4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid biosynthesis, omega-3 fatty acid metabolism7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects the balance of desaturation and elongation of fatty acids, where FADS enzymes play a crucial role in converting fatty acid precursors.10[1], 11[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1 and FADS2 are associated with altered fatty acid metabolism and blood lipid levels, including cholesterol.12[1], 13[2], 14[3], 15[4] This altered lipid profile is a known risk factor for cholelithiasis and type 2 diabetes.16[5], 17[6], 18[7], 19[8]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data