1-palmitoyl-2-palmitoleoyl-gpc (16:0/16:1)* to docosatrienoate (22:3n6)*

Numerator Metabolite

Structure of 1-palmitoyl-2-palmitoleoyl-gpc (16:0/16:1)*
Metabolite Accession: GCST90200038
Name: 1-palmitoyl-2-palmitoleoyl-gpc (16:0/16:1)*
Hmdb Id: HMDB0007969
Super Pathway: NA
Sub Pathway: NA
Inchikey: QIBZFHLFHCIUOT

Denominator Metabolite

Structure of docosatrienoate (22:3n6)*
Metabolite Accession: GCST90200138
Name: docosatrienoate (22:3n6)*
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.254
Position:
61588305
SE (Ratio):
0.023
Effect Allele:
G
Z-score (Ratio):
10.899
Reference Allele:
A
-log10(P):
-62.016
MAF:
0.344
Beta (Num):
0.064
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.190
SE (Den):
0.021
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylcholine biosynthesis.5[1], 6[2]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis (n-6).7[1], 8[2]

Ratio Explanation:

This ratio reflects the balance between glycerophospholipid synthesis and the production of long-chain polyunsaturated fatty acids, both influenced by FADS enzyme activity.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS gene variants alter FADS1/FADS2 desaturase activity, impacting the balance of fatty acids and influencing lipid metabolism.9[1], 3[2], 4[3], 10[4] This dysregulation is associated with an increased risk for cholelithiasis, type 2 diabetes, and other metabolic disorders.3[5], 11[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data