1-stearoyl-2-linoleoyl-gpe (18:0/18:2)* to 1-stearoyl-gpc (18:0)

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpe (18:0/18:2)*
Metabolite Accession: GCST90200039
Name: 1-stearoyl-2-linoleoyl-gpe (18:0/18:2)*
Hmdb Id: HMDB0008994
Super Pathway: NA
Sub Pathway: NA
Inchikey: YDTWOEYVDRKKCR

Denominator Metabolite

Structure of 1-stearoyl-gpc (18:0)
Metabolite Accession: GCST90199732
Name: 1-stearoyl-gpc (18:0)
Hmdb Id: HMDB0010384
Super Pathway: NA
Sub Pathway: NA
Inchikey: IHNKQIMGVNPMTC

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.379
Position:
61588305
SE (Ratio):
0.020
Effect Allele:
G
Z-score (Ratio):
18.662
Reference Allele:
A
-log10(P):
-177.299
MAF:
0.344
Beta (Num):
0.282
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.097
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism.7[1], 8[2], 9[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.10[1], 11[2]

Ratio Explanation:

The ratio reflects the conversion of linoleoyl-containing ethanolamine phosphoglycerides to other forms, a process influenced by FADS enzymes that desaturate fatty acid chains.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity, indicated by the metabolite ratio, is linked to valvular heart disease12[1], 13[2], 14[3], 15[4], cholelithiasis16[5], 17[6], 18[7], and asthma19[8], 20[9], 21[10], 22[11], 23[12]. This suggests altered inflammation and lipid signaling contribute to these conditions.

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data