1-stearoyl-2-linoleoyl-gpe (18:0/18:2)* to 1-arachidonoyl-gpe (20:4n6)*

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpe (18:0/18:2)*
Metabolite Accession: GCST90200039
Name: 1-stearoyl-2-linoleoyl-gpe (18:0/18:2)*
Hmdb Id: HMDB0008994
Super Pathway: NA
Sub Pathway: NA
Inchikey: YDTWOEYVDRKKCR

Denominator Metabolite

Structure of 1-arachidonoyl-gpe (20:4n6)*
Metabolite Accession: GCST90199791
Name: 1-arachidonoyl-gpe (20:4n6)*
Hmdb Id: HMDB0011517
Super Pathway: NA
Sub Pathway: NA
Inchikey: ROPRRXYVXLDXQO

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.652
Position:
61588305
SE (Ratio):
0.020
Effect Allele:
G
Z-score (Ratio):
31.867
Reference Allele:
A
-log10(P):
-511.433
MAF:
0.344
Beta (Num):
0.282
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.370
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Arachidonic acid metabolism

Ratio Explanation:

This ratio reflects the conversion of linoleoyl-GPE to arachidonoyl-GPE, a key step in omega-6 fatty acid synthesis regulated by FADS1 and FADS2 enzymes.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter enzyme activity, impacting the balance of omega-6 fatty acids.1[1], 2[2] This dysregulation of lipid mediators affects inflammatory and metabolic pathways, contributing to the diverse associated phenotypes like cholelithiasis, type 2 diabetes, and asthma.5[3], 6[4], 7[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data