1-stearoyl-2-linoleoyl-gpe (18:0/18:2)* to 1-lignoceroyl-gpc (24:0)

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpe (18:0/18:2)*
Metabolite Accession: GCST90200039
Name: 1-stearoyl-2-linoleoyl-gpe (18:0/18:2)*
Hmdb Id: HMDB0008994
Super Pathway: NA
Sub Pathway: NA
Inchikey: YDTWOEYVDRKKCR

Denominator Metabolite

Metabolite Accession: GCST90199895
Name: 1-lignoceroyl-gpc (24:0)
Hmdb Id: HMDB0010405
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.406
Position:
61557803
SE (Ratio):
0.022
Effect Allele:
C
Z-score (Ratio):
18.745
Reference Allele:
T
-log10(P):
-178.845
MAF:
0.346
Beta (Num):
0.277
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.129
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Peroxisomal VLCFA metabolism.6[1], 7[2]

Ratio Explanation:

This ratio reflects the balance between glycerophospholipids containing polyunsaturated fatty acids (PUFAs), whose synthesis is regulated by FADS enzymes, and very-long-chain fatty acid (VLCFA) species.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1/FADS2 polymorphisms alter desaturase activity, affecting polyunsaturated fatty acid levels.2[1], 8[2] This dysregulates lipid metabolism and inflammatory pathways, contributing to phenotypes like Type 2 diabetes, lipoprotein disorders, and cholelithiasis.9[3], 10[4], 11[5], 12[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data