1-stearoyl-2-linoleoyl-gpe (18:0/18:2)* to 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpe (18:0/18:2)*
Metabolite Accession: GCST90200039
Name: 1-stearoyl-2-linoleoyl-gpe (18:0/18:2)*
Hmdb Id: HMDB0008994
Super Pathway: NA
Sub Pathway: NA
Inchikey: YDTWOEYVDRKKCR

Denominator Metabolite

Metabolite Accession: GCST90200051
Name: 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs12928099

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
-0.252
Position:
15150505
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
-14.339
Reference Allele:
C
-log10(P):
-105.699
MAF:
0.290
Beta (Num):
-0.091
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.162
SE (Den):
0.017
No CNV overlap
rQTL cluster:
34
Reaction Distance:
NA
Closest Genes:
PDXDC1 NTAN1 RRN3 NPIPA1 NOMO1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylethanolamine biosynthesis.2[1], 3[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylcholine biosynthesis.4[1], 5[2]

Ratio Explanation:

The ratio reflects the balance between a phosphatidylethanolamine and a phosphatidylcholine, both key components of cell membranes whose synthesis pathways are distinct but interconnected.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered NOMO1 function may disrupt the insertion of key enzymes in phospholipid synthesis into the ER membrane, affecting the balance of different phospholipid classes. This dysregulation of lipid composition could contribute to altered plasma lipid profiles, including HDL and triglycerides, by affecting lipoprotein assembly and metabolism.1[1], 6[2], 7[3], 8[4], 9[5]

Phenotype Driver:

Gene-centric:NOMO1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data