1-stearoyl-2-linoleoyl-gpe (18:0/18:2)* to 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpe (18:0/18:2)*
Metabolite Accession: GCST90200039
Name: 1-stearoyl-2-linoleoyl-gpe (18:0/18:2)*
Hmdb Id: HMDB0008994
Super Pathway: NA
Sub Pathway: NA
Inchikey: YDTWOEYVDRKKCR

Denominator Metabolite

Structure of 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*
Metabolite Accession: GCST90200054
Name: 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*
Hmdb Id: HMDB0005323
Super Pathway: NA
Sub Pathway: NA
Inchikey: DRIVXEVMDWCWLI

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.418
Position:
61588305
SE (Ratio):
0.015
Effect Allele:
G
Z-score (Ratio):
28.562
Reference Allele:
A
-log10(P):
-411.482
MAF:
0.344
Beta (Num):
0.282
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.136
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Phosphatidylethanolamine biosynthesis, Glycerophospholipid metabolism. 3[1], 4[2]

Denominator Metabolite Explanation:

Phosphatidylethanolamine biosynthesis, Glycerophospholipid metabolism. 5[1], 6[2]

Ratio Explanation:

The ratio of a GPE with linoleic acid (18:2) to one with arachidonic acid (20:4) serves as a proxy for FADS1/FADS2 desaturase activity.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in the FADS cluster alter FADS1/FADS2 activity, impacting the balance of omega-6 fatty acids like linoleic and arachidonic acid. 1[1], 7[2], 2[3]This dysregulation of lipid metabolism is linked to phenotypes like pure hypercholesterolemia and other disorders of lipoprotein metabolism. 7[4], 8[5], 9[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data