1-stearoyl-2-linoleoyl-gpe (18:0/18:2)* to 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpe (18:0/18:2)*
Metabolite Accession: GCST90200039
Name: 1-stearoyl-2-linoleoyl-gpe (18:0/18:2)*
Hmdb Id: HMDB0008994
Super Pathway: NA
Sub Pathway: NA
Inchikey: YDTWOEYVDRKKCR

Denominator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*
Metabolite Accession: GCST90200058
Name: 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*
Hmdb Id: HMDB0005779
Super Pathway: NA
Sub Pathway: NA
Inchikey: URPXXNCTXCOATD

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.570
Position:
61588305
SE (Ratio):
0.024
Effect Allele:
G
Z-score (Ratio):
23.618
Reference Allele:
A
-log10(P):
-282.290
MAF:
0.344
Beta (Num):
0.282
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.288
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylethanolamine biosynthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Plasmalogen synthesis, Glycerophospholipid metabolism.5[1], 6[2]

Ratio Explanation:

The ratio reflects FADS2 desaturase activity, comparing a glycerophospholipid containing the precursor linoleic acid (18:2) to a plasmalogen containing the product arachidonic acid (20:4).7[1]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in the FADS gene cluster (FADS1/FADS2) alter polyunsaturated fatty acid metabolism.8[1], 9[2], 10[3] This dysregulation of fatty acids, which are precursors for inflammatory mediators, influences susceptibility to inflammatory and metabolic disorders like cholelithiasis, asthma, and Type 2 diabetes.7[4], 11[5]

Phenotype Driver:

Gene-centric:FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data