1-stearoyl-2-linoleoyl-gpe (18:0/18:2)* to arachidonoylcarnitine (c20:4)

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpe (18:0/18:2)*
Metabolite Accession: GCST90200039
Name: 1-stearoyl-2-linoleoyl-gpe (18:0/18:2)*
Hmdb Id: HMDB0008994
Super Pathway: NA
Sub Pathway: NA
Inchikey: YDTWOEYVDRKKCR

Denominator Metabolite

Structure of arachidonoylcarnitine (c20:4)
Metabolite Accession: GCST90200150
Name: arachidonoylcarnitine (c20:4)
Hmdb Id: HMDB0006455
Super Pathway: NA
Sub Pathway: NA
Inchikey: RBFQHRALHSUPIA

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.548
Position:
61588305
SE (Ratio):
0.024
Effect Allele:
G
Z-score (Ratio):
22.766
Reference Allele:
A
-log10(P):
-262.493
MAF:
0.344
Beta (Num):
0.282
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.267
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Phosphatidylethanolamine biosynthesis, Glycerophospholipid metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, Carnitine shuttle.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects the balance between glycerophospholipid synthesis (numerator) and fatty acid breakdown for energy (denominator), influenced by FADS desaturase activity on arachidonic acid.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity alters the availability of arachidonic acid, a key component of both metabolites, impacting cell membrane composition and inflammatory pathways. This dysregulation is linked to hypercholesterolemia, cholelithiasis, and type 2 diabetes, which are associated with altered lipid metabolism and inflammation.3[1], 10[2], 11[3], 12[4], 13[5], 14[6], 15[7], 16[8], 17[9]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data