1-stearoyl-2-linoleoyl-gpe (18:0/18:2)* to 1-palmitoyl-2-arachidonoyl-gpc (16:0/20:4n6)

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpe (18:0/18:2)*
Metabolite Accession: GCST90200039
Name: 1-stearoyl-2-linoleoyl-gpe (18:0/18:2)*
Hmdb Id: HMDB0008994
Super Pathway: NA
Sub Pathway: NA
Inchikey: YDTWOEYVDRKKCR

Denominator Metabolite

Structure of 1-palmitoyl-2-arachidonoyl-gpc (16:0/20:4n6)
Metabolite Accession: GCST90200692
Name: 1-palmitoyl-2-arachidonoyl-gpc (16:0/20:4n6)
Hmdb Id: HMDB0007982
Super Pathway: NA
Sub Pathway: NA
Inchikey: IIZPXYDJLKNOIY

Associated Genomic Regions

Region: rs174528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.820
Position:
61543499
SE (Ratio):
0.022
Effect Allele:
C
Z-score (Ratio):
38.122
Reference Allele:
T
-log10(P):
-730.512
MAF:
0.370
Beta (Num):
0.265
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.555
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
MYRF TMEM258 FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism.3[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, PUFA biosynthesis.4[1], 5[2], 6[3]

Ratio Explanation:

This ratio reflects FADS1/FADS2 enzyme activity, comparing a phospholipid containing a linoleic acid (precursor) to one with an arachidonic acid (product) moiety.1[1], 5[2], 7[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 alters polyunsaturated fatty acid (PUFA) synthesis, reflected by the ratio. This imbalance in lipid composition is causally linked to disorders of lipoprotein metabolism, hypercholesterolemia, and cholelithiasis by affecting systemic lipid levels and inflammatory processes.2[1], 8[2], 9[3], 10[4], 11[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data