sphingomyelin (d18:2/24:1, d18:1/24:2)* to 1-linoleoyl-gpc (18:2)

Numerator Metabolite

Metabolite Accession: GCST90200040
Name: sphingomyelin (d18:2/24:1, d18:1/24:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-linoleoyl-gpc (18:2)
Metabolite Accession: GCST90199742
Name: 1-linoleoyl-gpc (18:2)
Hmdb Id: HMDB0010386
Super Pathway: NA
Sub Pathway: NA
Inchikey: SPJFYYJXNPEZDW

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.203
Position:
61569830
SE (Ratio):
0.019
Effect Allele:
T
Z-score (Ratio):
-10.441
Reference Allele:
C
-log10(P):
-57.091
MAF:
0.339
Beta (Num):
-0.074
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.129
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Linoleate metabolism.6[1], 7[2]

Ratio Explanation:

The ratio reflects the activity of FADS enzymes, which influence the fatty acid composition of both sphingolipids and glycerophospholipids, thus impacting membrane biology.8[1], 9[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters fatty acid desaturation, affecting the balance of pro-inflammatory and anti-inflammatory lipid mediators.10[1], 11[2], 12[3], 13[4] This dysregulation is linked to inflammatory conditions like IBD and cardiovascular diseases such as valvular heart disease and hypercholesterolemia.14[5], 15[6], 16[7], 17[8]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data