sphingomyelin (d18:2/24:1, d18:1/24:2)* to 1-oleoyl-gpi (18:1)

Numerator Metabolite

Metabolite Accession: GCST90200040
Name: sphingomyelin (d18:2/24:1, d18:1/24:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-oleoyl-gpi (18:1)
Metabolite Accession: GCST90199822
Name: 1-oleoyl-gpi (18:1)
Hmdb Id: HMDB0061693
Super Pathway: NA
Sub Pathway: NA
Inchikey: UGDOFRYHDCDVHD

Associated Genomic Regions

Region: rs174599

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.176
Position:
61621556
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
-8.336
Reference Allele:
G
-log10(P):
-37.101
MAF:
0.375
Beta (Num):
-0.078
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
0.098
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS3 FADS1 RAB3IL1 FEN1

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid metabolism.4[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, GPI-anchor biosynthesis.5[1], 6[2]

Ratio Explanation:

The ratio reflects FADS enzyme activity, balancing specific sphingomyelin species against a GPI-anchored lipid, indicating shifts in fatty acid flux between these pathways.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Variations in FADS1/FADS2 alter polyunsaturated fatty acid levels, impacting both lipid metabolism and inflammation.7[1], 8[2] This systemic change is reflected in the sphingomyelin to GPI ratio and linked to phenotypes like hypercholesterolemia, dermatitis, and asthma.3[3], 9[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data