sphingomyelin (d18:2/24:1, d18:1/24:2)* to 1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)*

Numerator Metabolite

Metabolite Accession: GCST90200040
Name: sphingomyelin (d18:2/24:1, d18:1/24:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)*
Metabolite Accession: GCST90200070
Name: 1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)*
Hmdb Id: HMDB0011207
Super Pathway: NA
Sub Pathway: NA
Inchikey: FZMYLOBGNYZPQO

Associated Genomic Regions

Region: rs72719193

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
0.337
Position:
67969108
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
23.766
Reference Allele:
G
-log10(P):
-285.801
MAF:
0.478
Beta (Num):
0.010
Novel Locus:
No
SE (Num):
0.014
Beta (Den):
-0.327
SE (Den):
0.014
No CNV overlap
rQTL cluster:
46
Reaction Distance:
NA
Closest Genes:
TMEM229B PLEKHH1 PIGH PLEK2 EIF2S1

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid biosynthesis/metabolism.4[1], 5[2], 6[3], 7[4]

Denominator Metabolite Explanation:

Plasmalogen biosynthesis.8[1], 9[2], 10[3]

Ratio Explanation:

An inverse relationship between a sphingomyelin and a choline plasmalogen may suggest a shift in membrane composition or signaling pathways, but the role of TMEM229B is unknown.

Ratio Evidence:

metabolites unrelated

Gene Ratio Phenotype Relationship:

The provided data is insufficient to establish a clear and evidence-based causal link between the TMEM229B gene, the specified metabolite ratio, and any potential phenotype.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data