sphingomyelin (d18:2/24:1, d18:1/24:2)* to 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*

Numerator Metabolite

Metabolite Accession: GCST90200040
Name: sphingomyelin (d18:2/24:1, d18:1/24:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*
Metabolite Accession: GCST90200073
Name: 1-linoleoyl-2-arachidonoyl-gpc (18:2/20:4n6)*
Hmdb Id: HMDB0008147
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZZSZQATYGVHNLZ

Associated Genomic Regions

Region: rs9366722

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.176
Position:
11087780
SE (Ratio):
0.021
Effect Allele:
T
Z-score (Ratio):
-8.382
Reference Allele:
C
-log10(P):
-37.493
MAF:
0.244
Beta (Num):
-0.069
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.107
SE (Den):
0.018
No CNV overlap
rQTL cluster:
112
Reaction Distance:
NA
Closest Genes:
SMIM13 ERVFRD-1 ELOVL2 NEDD9 SYCP2L

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Arachidonic acid metabolism.6[1], 7[2], 8[3]

Ratio Explanation:

This ratio may reflect the activity of ELOVL2 in elongating fatty acids, impacting the balance between very-long-chain sphingolipids and long-chain glycerophospholipids.9[1], 2[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data