sphingomyelin (d18:2/24:1, d18:1/24:2)* to 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*

Numerator Metabolite

Metabolite Accession: GCST90200040
Name: sphingomyelin (d18:2/24:1, d18:1/24:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Metabolite Accession: GCST90200080
Name: 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Hmdb Id: HMDB0009783
Super Pathway: NA
Sub Pathway: NA
Inchikey: PDLAMJKMOKWLAJ

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.183
Position:
61588305
SE (Ratio):
0.021
Effect Allele:
G
Z-score (Ratio):
-8.604
Reference Allele:
A
-log10(P):
-39.405
MAF:
0.344
Beta (Num):
-0.077
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
0.106
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

GPI anchor biosynthesis.5[1], 6[2]

Ratio Explanation:

This ratio may reflect FADS1/FADS2 activity, which alters the fatty acid composition of both sphingolipids and GPI-anchors, key components of cell membranes.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 are linked to altered polyunsaturated fatty acid levels, impacting both inflammatory and lipidemic phenotypes.7[1], 8[2], 9[3], 10[4] The ratio of these distinct lipid classes likely serves as a biomarker for FADS activity influencing downstream inflammatory and metabolic pathways.11[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data