1-palmitoyl-2-stearoyl-gpc (16:0/18:0) to docosatrienoate (22:3n3)

Numerator Metabolite

Structure of 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Metabolite Accession: GCST90200041
Name: 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Hmdb Id: HMDB0007970
Super Pathway: NA
Sub Pathway: NA
Inchikey: PZNPLUBHRSSFHT

Denominator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.465
Position:
61581764
SE (Ratio):
0.024
Effect Allele:
C
Z-score (Ratio):
-19.074
Reference Allele:
T
-log10(P):
-185.080
MAF:
0.308
Beta (Num):
-0.232
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.233
SE (Den):
0.018
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Long-chain unsaturated fatty acid synthesis

Ratio Explanation:

This ratio reflects FADS1 activity, contrasting a structural membrane lipid (1-palmitoyl-2-stearoyl-gpc) with a polyunsaturated fatty acid (docosatrienoate) whose synthesis FADS1 regulates.1[1], 5[2], 6[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1 variants, identified through eQTL, alter its enzymatic activity, which impacts the balance of pro- and anti-inflammatory polyunsaturated fatty acids.1[1], 7[2], 8[3] This dysregulation is linked to inflammatory conditions like asthma and dermatitis, and disorders of lipid metabolism, such as hypercholesterolemia.3[4], 9[5], 10[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data