1-palmitoyl-2-stearoyl-gpc (16:0/18:0) to 1-linoleoyl-gpc (18:2)

Numerator Metabolite

Structure of 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Metabolite Accession: GCST90200041
Name: 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Hmdb Id: HMDB0007970
Super Pathway: NA
Sub Pathway: NA
Inchikey: PZNPLUBHRSSFHT

Denominator Metabolite

Structure of 1-linoleoyl-gpc (18:2)
Metabolite Accession: GCST90199742
Name: 1-linoleoyl-gpc (18:2)
Hmdb Id: HMDB0010386
Super Pathway: NA
Sub Pathway: NA
Inchikey: SPJFYYJXNPEZDW

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.339
Position:
61569830
SE (Ratio):
0.017
Effect Allele:
T
Z-score (Ratio):
-19.536
Reference Allele:
C
-log10(P):
-194.022
MAF:
0.339
Beta (Num):
-0.210
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.129
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid biosynthesis3[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Lysophospholipid metabolism4[1]

Ratio Explanation:

This ratio compares a phosphatidylcholine with saturated fatty acids to a lysophosphatidylcholine with a polyunsaturated fatty acid, potentially reflecting FADS1/FADS2 desaturase activity.2[1], 5[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity, indicated by a higher ratio of saturated to unsaturated fatty acids, is associated with altered blood lipid profiles, including cholesterol.6[1], 7[2] This dyslipidemia is a known risk factor for pure hypercholesterolaemia.

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data