1-palmitoyl-2-stearoyl-gpc (16:0/18:0) to 1-linoleoyl-gpi (18:2)*

Numerator Metabolite

Structure of 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Metabolite Accession: GCST90200041
Name: 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Hmdb Id: HMDB0007970
Super Pathway: NA
Sub Pathway: NA
Inchikey: PZNPLUBHRSSFHT

Denominator Metabolite

Structure of 1-linoleoyl-gpi (18:2)*
Metabolite Accession: GCST90199821
Name: 1-linoleoyl-gpi (18:2)*
Hmdb Id: HMDB0240597
Super Pathway: NA
Sub Pathway: NA
Inchikey: SAHCQBPGXQFTRA

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.393
Position:
61581764
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
-18.786
Reference Allele:
T
-log10(P):
-179.618
MAF:
0.308
Beta (Num):
-0.232
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.161
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylcholine Biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylinositol phosphate metabolism.6[1], 7[2]

Ratio Explanation:

The ratio reflects FADS1 activity; higher activity leads to greater desaturation of fatty acids, influencing the balance between saturated PC and unsaturated PI lipids.8[1], 9[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1 activity alters the balance of saturated and polyunsaturated fatty acids incorporated into phospholipids. This shift impacts inflammatory pathways and lipid profiles, contributing to phenotypes like hypercholesterolemia, phlebitis, and asthma.2[1], 10[2], 11[3], 12[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data