1-palmitoyl-2-stearoyl-gpc (16:0/18:0) to 1-oleoyl-gpi (18:1)

Numerator Metabolite

Structure of 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Metabolite Accession: GCST90200041
Name: 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Hmdb Id: HMDB0007970
Super Pathway: NA
Sub Pathway: NA
Inchikey: PZNPLUBHRSSFHT

Denominator Metabolite

Structure of 1-oleoyl-gpi (18:1)
Metabolite Accession: GCST90199822
Name: 1-oleoyl-gpi (18:1)
Hmdb Id: HMDB0061693
Super Pathway: NA
Sub Pathway: NA
Inchikey: UGDOFRYHDCDVHD

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.324
Position:
61581764
SE (Ratio):
0.020
Effect Allele:
C
Z-score (Ratio):
-16.000
Reference Allele:
T
-log10(P):
-130.994
MAF:
0.308
Beta (Num):
-0.232
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.092
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Glycerophospholipid metabolism

Ratio Explanation:

This ratio compares a saturated phosphatidylcholine (PC) to a monounsaturated phosphatidylinositol (PI), potentially reflecting FADS-mediated desaturase activity on the fatty acid precursors.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 likely alters desaturase activity, impacting fatty acid availability. This change, reflected by the ratio, influences membrane composition and inflammatory signaling, contributing to associated phenotypes like asthma, hypercholesterolemia, and phlebitis.3[1], 4[2], 5[3], 6[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data