1-palmitoyl-2-stearoyl-gpc (16:0/18:0) to 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*

Numerator Metabolite

Structure of 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Metabolite Accession: GCST90200041
Name: 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Hmdb Id: HMDB0007970
Super Pathway: NA
Sub Pathway: NA
Inchikey: PZNPLUBHRSSFHT

Denominator Metabolite

Metabolite Accession: GCST90200051
Name: 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.563
Position:
61581764
SE (Ratio):
0.020
Effect Allele:
C
Z-score (Ratio):
-28.415
Reference Allele:
T
-log10(P):
-407.288
MAF:
0.308
Beta (Num):
-0.232
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.331
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, fatty acid metabolism.4[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, polyunsaturated fatty acid biosynthesis.1[1], 5[2]

Ratio Explanation:

The ratio reflects FADS1 desaturase activity, comparing a phosphatidylcholine with a saturated fatty acid (stearoyl) to one with a polyunsaturated fatty acid (dihomo-linolenoyl).

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS1 activity, indicated by the metabolite ratio, impacts the synthesis of pro-inflammatory and anti-inflammatory lipid mediators derived from polyunsaturated fatty acids.1[1], 6[2], 7[3] This dysregulation is linked to inflammatory conditions like asthma and dermatitis, as well as disorders of lipid metabolism.8[4], 9[5], 7[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data